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Evidence & Research Literacy glossary

Statistical significance: meaning, context, and what to check.

A statistical indication evaluated under a defined model; it does not automatically mean an effect is large, important, or useful.

IPA and plain-English pronunciationDirect answer and decision contextSources and review date

Definition in one sentence

What does Statistical significance mean?

A statistical indication evaluated under a defined model; it does not automatically mean an effect is large, important, or useful.

How to pronounce Statistical significance

stuh-TIS-tih-kuhl sig-NIF-ih-kuhns

IPA/stə.ˈtɪ.stɪ.kəl səɡ.ˈnɪ.fɪ.kəns/Sounds likestuh-TIS-tih-kuhl sig-NIF-ih-kuhns

Common American English pronunciation.

TopicEvidence & Research Literacy
Pronunciationstuh-TIS-tih-kuhl sig-NIF-ih-kuhns
Editorial depthComplete review
ReviewedAugust 2026
Why it matters

The result helps assess compatibility with a null hypothesis, but it does not tell you how large, useful, durable, safe, or credible the effect is.

What it does not prove

Statistical significance does not prove causation, eliminate bias, establish clinical importance, or guarantee replication.

What to check
  • Find the prespecified primary outcome and analysis rather than selecting one favorable result.
  • Review effect size and confidence interval alongside the p-value.
  • Check sample size, missing data, multiple comparisons, and analysis changes.
  • Ask whether the effect is meaningful, reproducible, and relevant to the claim.

Start with the useful meaning

Statistical significance in plain English

Statistical significance indicates that an observed result meets a prespecified statistical threshold under a particular model, often expressed with a p-value or confidence interval.

Where you may encounter this term

Clinical-trial results

Research abstracts

Meta-analyses

Marketing summaries of studies

Example

How does Statistical significance appear in a real decision?

Practical example

A large trial detects a very small difference that reaches the statistical threshold. The number may be statistically significant while being too small to matter in a person’s daily life.

Decision context

Why does Statistical significance matter?

The result helps assess compatibility with a null hypothesis, but it does not tell you how large, useful, durable, safe, or credible the effect is.

Label and use checklist

What should you check when you see Statistical significance?

  • Find the prespecified primary outcome and analysis rather than selecting one favorable result.
  • Review effect size and confidence interval alongside the p-value.
  • Check sample size, missing data, multiple comparisons, and analysis changes.
  • Ask whether the effect is meaningful, reproducible, and relevant to the claim.

Claim boundary

What does Statistical significance not prove?

Statistical significance does not prove causation, eliminate bias, establish clinical importance, or guarantee replication.

Avoid the shortcut

How should you compare Statistical significance carefully?

Comparison rule

Statistical significance addresses a statistical threshold. Clinical significance addresses practical importance, and confidence intervals show the range of effect sizes compatible with the data.

Clear the shortcuts

What are common misunderstandings about Statistical significance?

A p-value below 0.05 proves the hypothesis is true.

A nonsignificant result proves there is no effect.

Statistical significance tells you the size of a benefit.

PAA-style answers

Questions people also ask about Statistical significance

What is Statistical significance?

A statistical indication evaluated under a defined model; it does not automatically mean an effect is large, important, or useful.

How do you pronounce Statistical significance?

A common American English pronunciation is stuh-TIS-tih-kuhl sig-NIF-ih-kuhns. In the International Phonetic Alphabet, it is written /stə.ˈtɪ.stɪ.kəl səɡ.ˈnɪ.fɪ.kəns/.

What does Statistical significance mean?

A statistical indication evaluated under a defined model; it does not automatically mean an effect is large, important, or useful.

Why does Statistical significance matter?

The result helps assess compatibility with a null hypothesis, but it does not tell you how large, useful, durable, safe, or credible the effect is.

What should you check when you see Statistical significance?

Find the prespecified primary outcome and analysis rather than selecting one favorable result. Review effect size and confidence interval alongside the p-value.

What does Statistical significance not prove?

Statistical significance does not prove causation, eliminate bias, establish clinical importance, or guarantee replication.

Maintained reference

Sources, review, and corrections

This definition uses authoritative labeling, taxonomy, research-literacy, or cultivation sources and applies them conservatively to consumer decisions.

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